What is the Most Expensive Way to Finance Your Real Estate Deals?

I knew as soon as I started reading what the question and answer were going to be. As with most things in real estate and investing in general, the answer to almost all questions will be "it depends." And if you spin the circumstances in the right way, you can justify almost any answer.

In this case, the guy obviously wanted to be provocative and/or controversial, so he gave a question and some circumstances where the "right" answer would have that effect.

That said, for me and my situation, I agree with Jon. If I were to use loans for all my deals, my cost of capital would be much, much, much higher than what I was earning on my cash sitting in the bank. That doesn't make any sense unless there were some other advantages to holding that cash in the bank.

If the thought is that I'll want to do more deals than I have cash, then it makes sense for any successful investor to finance (your returns will generally be higher than your cost of capital), but it wouldn't be financially prudent to finance the first set of properties and then use your cash on the later ones -- it would make more fiscal sense to use your cash first and finance later. This reduces your overall cost of capital by ensuring your only paying for money when you absolutely need it.

Of course, there are situations where cash might be more "expensive" than financing. But, these are generally situations where there's an opportunity cost to using cash now versus later. The most common situation would be where you would finance a deal now in order to preserve cash for a later deal that couldn't be financed -- and if you didn't have the cash, you couldn't do the later deal.

But, my assessment above presumes that all deals are essentially the same, and any of them could be cash or could be financed, so this situation doesn't apply.

Again, everyone will be in a different situation, but for me, I prefer to use about 70% of my cash before I consider financing, saving the 30% in case any cash-only deals come along...

J Scott, Lish Properties, LLC
E-Mail: j@123flip.com
Telephone: 770-906-6358
Website: http://www.123flip.com

Source: http://www.biggerpockets.com/forums/67/topics/78556-what-is-the-most-expensive-way-to-finance-your-real-estate-deals

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Weak earnings reports weigh on stocks

Stocks were mostly lower Friday in response to weak corporate earnings reports. Tepid economic growth in the US also pushed stocks down.

By Joshua Freed,?AP Business Writer / October 26, 2012

A trader works on the floor of the New York Stock Exchange, Friday. Stocks rose in the morning before a mild midday sell-off, then recovered somewhat in the afternoon.

Brendan McDermid/Reuters

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Stocks?closed mostly lower Friday after investors found little to like in weak corporate earnings reports and news of only tepid growth in the U.S. economy in the third quarter.

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The Dow Jones industrial average managed a gain of 3.53 points to close at 13,107.21 after spending much of the day in the red.

The Standard & Poor's 500 index fell 1.03 points to 1,411.94 and the Nasdaq composite rose 1.83 points to 2,987.95.

Stocks?rose in the morning before a mild midday sell-off, then recovered somewhat in the afternoon.

The morning gains came after the Commerce Department estimated that the U.S. economy expanded at a 2 percent annual rate from July through September. That was better than the previous quarter, and better than analysts expected, but not strong enough to bring down the unemployment rate.

Even economic data that is mixed or positive won't outweigh weak earnings, said Lawrence Creatura, a portfolio manager with Federated Investors. Reports like the one on Friday that measure gross domestic product tend to be backwards-looking, while companies are offering forecasts about the months ahead, he said.

"Company earnings trump macro data. Because investors own Apple, they don't own GDP," Creatura said.

Apple fell $5.54 to $604 after saying its profit will decline this holiday season.

Even with Friday's rise,?stocks?lost ground this week, inflecting a sort of death-by-a-thousand-cuts on the rally that began in September. The Dow was down 236.30 points for the week, or 1.8 percent. The S&P has fallen 21.25 points, or 1.5 percent.

Goodyear Tire & Rubber sank 10 percent after a steep dropoff in sales in Europe delivered a blow to its earnings. The?stock?fell $1.28 to $11.02.

The advertising conglomerate Interpublic also turned in results that fell short of analysts' forecasts, and itsstock?fell 2.5 percent, or 26 cents, to $10.29.

Amazon rose $15.32, or 7 percent, to $238.24 despite a smaller-than-expected quarterly profit and a prediction for smaller-than-expected holiday revenue.

Among other companies making big moves, cable TV provider Comcast jumped $1.20, or 3.3 percent, to $37.56 after reporting that its income more than doubled in the latest quarter. Revenue was higher than analysts were expecting, and more customers signed up for premium services like high-definition video recorders.

Varian Medical Systems jumped $8.83, or 15 percent, to $66.93, the biggest increase in the S&P 500 index. The company, which sells medical imaging equipment and radiation-emitting devices for treating tumors, reported a 20 percent rise in income because of higher sales of devices.

On its first day of trading, dairy company WhiteWave Foods lost 25 cents to $16.75, down from its initial public offering price of $17, after rising as high as $19.17 earlier.

The yield on the 10-year Treasury note fell to 1.75 percent from 1.82 percent on Thursday.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/xH6PS1v_aoU/Weak-earnings-reports-weigh-on-stocks

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In Twitter We Trust: Can Social Media Sway Voters?

Social media sites, including Facebook and Twitter, have been important parts of this year's presidential campaigns. As Americans prepare to head to the polls, experts discuss social media's influence on politics, and whether Twitter can predict who will win the election.

Source: http://www.npr.org/2012/10/26/163712869/in-twitter-we-trust-can-social-media-sway-voters?ft=1&f=1007

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Daily Kos: Targeting Latino Voters in Campaign Communications ...

New approaches that seek to explain the cause of low Hispanic turnout and political participation focus on mobilization efforts targeted toward Hispanic voters. Research indicates that campaigns spend less time contacting Hispanic households than they do contacting African-Americans and non-Hispanic whites. According to the 2004?American National Election Studies?only 16 percent of Hispanics were contacted by political campaigns in that election cycle as opposed to 26 percent of blacks and 49 percent of whites. Moreover, the dominant language spoken inside Hispanic households is another potential explanation for low political participation among Hispanics. 2009 American Community Survey data shows that?35 million Americans?5 years of age and older spoke Spanish at home and close to half of these people did not speak English ?very well?. Only 28 percent of respondents to the?2006 Latino National Survey?said they could carry on a conversation ?very? or ?pretty? well in English.

Spanish language advertising has proven particularly effective to Hispanics who primarily speak Spanish or who struggle to carry out a conversation in English. Alternately, Hispanics who are highly incorporated into the political and social fabric of the United States and whose cultural connection to their native heritage is weaker than recent arrivals of Hispanic families, may be less responsive to appeals in Spanish and more receptive to political messages in English.?Minimal research in political science has examined how the language of political communication affects one?s political behavior.

However, Two recent studies examine the impact of language in political communication to Hispanic voters. Don Green and I analyzed whether Spanish-language radio can be used to increase Hispanic voter turnout. In?our experimental study, we ran nonpartisan 60-second, radio spots in 206 uncompetitive congressional districts close to the November 2006 midterm elections in order to reach voters typically ignored by political campaigns. The message urged voters to vote and provided some basic information about the congressional races, including the names of the candidates. These ads were aired in Spanish on radio stations that reached a wide Spanish-speaking audience during peak drive times.

Since 1980, Spanish language radio has exploded in popularity. Only television is a larger source for news among Hispanics, according to the?2004 Pew Hispanic Media Study. With a wide and consistent audience, Spanish language radio is a ripe venue for political campaigns to mobilize voters. Yet, radio?s impact on the political behavior of Hispanic voters has received scant attention.

The results of our field experiment imply that 100 gross ratings points (GRPs) of radio advertising increases Hispanic turnout by 4.3 percentage points on average. It seems nonpartisan radio ads urging Latinos to vote can effectively raise levels of participation. Given the cost efficiencies of mass media advertising, the cost effectiveness of radio advertising compares favorably to other forms of outreach, including grassroots tactics like door-to-door canvassing, direct mail and volunteer phone calls. But because the language of the appeals was not varied, the question of whether English language appeals effectively mobilize Hispanic voters remained open.

With UCSD?s Marisa Abrajano, I explored this question more directly in a?second field experiment?conducted in New York City?s 21^st?City Council District during the February 2009 special election. Special elections tend to be low turnout affairs that draw few competing political messages making such an environment ideal to study the effects of political communication produced by the language in which they are communicated.

The experiment established two randomly selected treatment groups that received postcard mailings shortly before the election. One group received a nonpartisan mailing in Spanish encouraging them to vote. The other mailer was exactly the same but in English, and the rest of the sample was randomly assigned to the control group and did not receive any mailing.

Those in the English language treatment group experienced a 2.2 percent increase in turnout on average compared to the 1.0 percentage point average increase for those in the Spanish language treatment group. Simply put, the study found more evidence that the English language mailer was more effective in mobilizing participants than the Spanish language mailer. This finding is of critical importance to campaigns because it suggests that they ought to reassess strategies that appeal to Hispanics entirely in Spanish. Spanish language appeals may be effective in stimulating electoral participation among Spanish-speaking Hispanics, but they are not necessarily more effective than messages delivered for English-speaking Hispanics.

Taken together, these studies suggest there is much still to learn about communicating with Latino voters during electoral campaigns. Approaches designed to mobilize and persuade Latinos are quite nuanced, and scholars have only begun to scratch the surface in terms of exploring these nuances. Studies conducted to explore these details further represent an opportunity for scholars to inform strategies adopted by practitioners and campaign professionals in unprecedented ways.

Costas Panagopoulos?is Associate Professor of Political Science and Director of the Center for Electoral Politics and Democracy and the Graduate Program in Elections and Campaign Management at Fordham University. ?The analysis discussed here is based on the original, and independent research of Dr. Panagopoulos, and not part of ?Latino Decisions study.

Source: http://www.dailykos.com/story/2012/10/25/1149997/-Targeting-Latino-Voters-in-Campaign-Communications-New-Evidence-and-Insights

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Jerusalem's secular Israeli minority showing life

JERUSALEM (AP) ? Hundreds of people packed a Jerusalem community center recently for what many in Jerusalem consider a subversive act: They attended a lecture on Saturday, the Jewish Sabbath.

The seemingly harmless event, in which the popular Arab-Israeli journalist Sayed Kashua talked about pluralism and tolerance, broke a long-standing ban on holding activities in public buildings on the Jewish day of rest.

That turned Kiryat Yovel, a tranquil neighborhood in west Jerusalem, into the latest battleground in Jerusalem's protracted culture war between Jewish conservatism and pluralism.

After years of setbacks, Jerusalem's secular population has begun to push back against what many believe are heavy-handed tactics by the city's ultra-Orthodox residents to impose their religious mores on the general population. A growing number of restaurants now open on Saturday, an array of cultural events have sprouted up, and for the first time in years, a longtime exodus of secular residents for nearby suburbs appears to have halted.

"We're not against the ultra-Orthodox, we're for tolerance and integration and against intimidation. But from no public services offered on Saturdays to promoting gender segregation, the community is undermining the very basis of our democratic state," said Dina Azriel, a leader in the grassroots "Free Kiryat Yovel" initiative, which sponsored the recent lecture.

While most Israelis are secular, Israel's founding fathers gave Judaism a formal place in the country's affairs, and Orthodox rabbis strictly govern religious events such as weddings, divorces, and burials for the Jewish population. The ultra-Orthodox are also perennial kingmakers in Israeli coalition politics, though they make up only about 10 percent of the country's population.

The influence of the ultra-Orthodox is especially pronounced in Jerusalem, where their numbers are proportionally much larger than the national average. Jerusalem, Israel's largest city, is split almost evenly into thirds between secular and modern Orthodox residents, Muslim Palestinians, and the ultra-Orthodox Jews.

Many modern Orthodox Jews live and work with the secular population while maintaining a religious life style, in contrast to ultra-Orthodox, who choose to live in insulated enclaves.

The ultra-religious have used their large numbers and political muscle to shape modern Jerusalem. The city grinds to a virtual standstill on the Jewish Sabbath, with businesses closed, public transportation halted and few options for entertainment.

Attempts to change this status quo have prompted violent backlashes from the ultra-Orthodox, who haven't hesitated to block roads, clash with police or send tens of thousands of activists into the streets when ordered by their rabbis. In 2009, the city experienced riots when it allowed a parking lot near Jerusalem's Old City to open on the Sabbath to serve out-of-town tourists.

In recent years, the ultra-Orthodox have grown bolder, pressuring the local bus company, Egged, to operate gender-segregated lines through religious neighborhoods, attempting to separate men and women on public sidewalks and ripping down billboards with female images on them. Because of the threat of vandalism, Egged recently decided to cease all advertising on its Jerusalem buses by October 2013.

Religious coercion could be an issue in January's parliamentary elections. Prime Minister Benjamin Netanyahu's government, which includes ultra-Orthodox parties, has been criticized as caving in to their demands. In particular, many secular Israelis are upset over the government's failure to end military draft exemptions for the ultra-Orthodox, despite a Supreme Court order.

The "Free Kiryat Yovel" movement was formed after ultra-Orthodox activists were allowed to build a kindergarten that maintained a wall to separate religious and non-religious preschoolers. It took four years of petitioning the local community center to win a permit for the Sabbath lecture.

"We're in a really critical time right now, and I'm not optimistic," said Sarit Hashkes, who runs another secular rights group, called "Be Free Israel."

"What we're seeing now is cooperation of state and police officials with the ultra-Orthodox. Women are being pushed aside, and everything is pushed more to the right."

The group is behind a number of initiatives, like offering discount cards to patrons to use at restaurants that are open on the Sabbath to increase "secular buying power."

Hashkes said momentum among the secular population is percolating, but not without an equally fierce backlash. While separate sidewalks are officially banned, she said some streets were still off limits to women during the recent Jewish Sukkot holiday.

Just last week, a prominent female activist was arrested for wearing a traditionally male prayer shawl at the Western Wall, the holiest place where Jews can pray, an act that police prohibit because of Orthodox Jewish sensitivities.

Anat Hoffman said police strip-searched her and jailed her overnight, releasing her only after she agreed to stay away from the site for a month. The incident occurred as she led prayers for 200 American Jewish women from Hadassah, a Jewish women's group that was celebrating its 100th anniversary.

Over the years, the growing religious influence, coupled with a high cost of living, has pushed tens of thousands of secular Jerusalemites to leave the city. Navigating a complicated balancing act, Mayor Nir Barkat, a secular, former high-tech businessman, has attempted to revive secular life in the city without alienating the ultra-Orthodox.

Barkat's office says the mayor has boosted the city's culture budgets since he was elected in 2008, quadrupling events like concerts and street festivals to enliven the city and encouraged new housing in secular areas to draw young couples and families.

"Despite a small number of friction points in the city, Jerusalem has seen a dramatic reduction in tension between the Ultra-Orthodox and secular communities in recent years," said spokesman Barak Cohen.

In a sign that secular life could be making a comeback, the mayor's office noted that enrollment in secular schools increased in the last school year for the first time in 15 years.

Naomi Tsur, a deputy mayor of Jerusalem, noted that for the first time in 15 years, there is a clear non-Orthodox majority in the city council, another sign of secular revival. Modern Orthodox schools also posted slight gains.

Whether these trends can continue remains unclear. More than 60 percent of Jewish students attend ultra-Orthodox schools, according to the Jerusalem Institute of Israel Studies.

Tsur, an urban planner who has promoted coexistence among Jerusalem's diverse populations, said "a lot will hinge" on whether the secular masses turn their concerns into election issues. "People usually go to vote on 'shall we go to war with Iran,' but we need to work together on making an appealing mix that will attract young and dynamic couples to live in Jerusalem," she said.

With parliamentary elections approaching, Kiryat Yovel activist and art historian Daniel Unger thinks these issues will continue to be pushed to the back burner.

"This is a real issue that Netanyahu and others don't want to address," he says. "Instead, he keeps talking about the Iranian bomb, in hope that his people won't pay attention to the domestic social and economic issues he's ignored."

Source: http://news.yahoo.com/jerusalems-secular-israeli-minority-showing-life-061001598.html

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U.S. zaps four out of five targets in missile defense test

WASHINGTON | Thu Oct 25, 2012 2:23pm EDT

WASHINGTON (Reuters) - The Pentagon on Thursday said it hit four out of five targets in its biggest, most complicated missile defense flight test to date.

The Missile Defense Agency said in a statement a fifth target -- a short-range ballistic missile -- did not appear to have been shot down successfully.

The live-fire demonstration was conducted at the U.S. Army's Kwajalein Atoll/Reagan Test Site in Hawaii and surrounding areas in the western Pacific and tested the Aegis Ballistic Missile Defense (BMD), Terminal High Altitude Area Defense (THAAD), and PATRIOT weapon systems.

The THAAD system, produced by Lockheed Martin Corp successfully intercepted its first Medium Range Ballistic target in history, the MDA said.

THAAD is a U.S. Army system designed to shoot down short-, medium- and intermediate-range ballistic missiles with an interceptor that slams into its target.

It can accept cues from Lockheed's Aegis weapons system, satellites and other external sensors and work in tandem with the PATRIOT Avanced Capability-3 terminal air-defense missile, also built by Lockheed.

In the test, a PAC-3 took down a short-range ballistic missile launched from a mobile platform in the ocean northeast of Kwajalein Atoll, MDA said.

(Reporting by Phil Stewart; editing by Andrew Hay)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/LihQazCg6Rw/us-usa-pentagon-missile-idUSBRE89O1E420121025

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HTC seeks to reverse sliding smartphone sales

TAIPEI, Taiwan (AP) ? Taiwan's HTC Corp. enjoyed three golden years as the first company to make smartphones based on Google's Android software. Now, it is struggling to halt a slide in sales and keep its status as a global brand in a market increasingly divided between Apple Inc. and Samsung Electronics Co.

An early maker of smartphones sold under brands like HP and Compaq, HTC started stamping its own brand on phones in 2006. Taiwanese company surged into the fast lane two years later with its Android smartphones that appealed to consumers because of competitive prices on the free operating system and their strong design.

But its sales faltered from the second half of 2011, partly because its limited financial resources put it at a strong disadvantage to aggressive marketing drives by Samsung and Apple. And unlike its American competitor, it lacked a distinctive flagship phone that captured the hearts of consumers as a must-have product. Instead it produced many phones, trying to cater to a wide range of consumers.

HTC on Friday reported a 79 percent drop in third quarter profit to 3.9 billion New Taiwan dollars ($99 million) on revenue of NT$70 billion. It was HTC's fourth consecutive fall in quarterly profit.

Worse may be to come. It predicted revenue will drop to NT$60 billion in the fourth quarter despite traditional pre-Christmas buying and its introduction of two new models running on Microsoft's Windows 8 software.

"HTC is undergoing a difficult period of trial and error," said Stephen Su, market analyst at Taiwan's Industrial Technology Research Institute.

"Its technology is good and its design capability is Taiwan's best," he said. "But like other Taiwanese makers, HTC falls behind in the area of practical application."

Su said HTC's unfamiliarity with Western markets puts it at a disadvantage in developing products for Western consumers ? in contrast to Apple, which always seems to be one step ahead of consumer sentiment, not only in the West, but all around the world.

HTC was founded in 1997 as a contract electronics manufacturer. Under its chief executive Peter Chou, the company focused decisively on smartphones in 2006, collaborating with U.S. carriers in marketing efforts.

HTC's performance reached its peak in the April-June period of 2011, when it shipped 12 million phones and its revenue totaled NT$125 billion.

The company's salvation may lie in pursuing alliances with tablet computer and TV makers so HTC phones can share entertainment and other programs with multiple devices just like iPhones do. The Taiwan maker has not publically addressed the question of a prospective alliance.

China's vast market could also offer HTC very good growth prospects. Economic ties and trade between China and Taiwan, which Beijing considers a breakaway province, have blossomed in recent years, providing new avenues of growth for many Taiwanese companies.

"The greater China market may be HTC's opportunity if they can make phones with features desired by the Chinese and possibly extend that experience to design products for Western consumers," said Su.

In China's fast growing smartphone market, HTC is expected to sell 6 million phones this year, ranking 10th, according to Taiwan's Topology Research Institute.

That would put it well behind Samsung's projected 32 million, Apple's 15 million and even Nokia's 11 million, the organization said. Total Chinese smartphone sales in 2013 will likely hit 256 million, up 36 percent on 2012, it said.

Dennis Chan, an analyst with Taiwan's Yuanta Core Pacific Securities, said that despite its current troubles, HTC can bounce back if it can come up with a new phone that resonates with consumers.

"The company is now rolling out only a few models instead of multiple phones to meet every taste as it used to," Chan said. "It will remain a recognized brand for high- and middle-end phones. But it needs to launch a flagship model with distinctive features to really turn things around."

Source: http://news.yahoo.com/htc-seeks-reverse-sliding-smartphone-sales-080034002--finance.html

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Thousands of pregnant women at risk from antidepressants, doctors ...

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Sprint sells 1.5 million iPhones, 1 million other smartphones, but makes a net loss of $767 million

Sprint's latest financials show that the network is stemming its losses, but is still taking a hit on a $767 million net loss and an operating loss of $231 million. Dan Hesse's company managed to bring in service revenues of $7.3 billion and added a further 900,000 customers in the period, but ate $397 million write-down as part of the Nextel shutdown.

Naturally, it's been a busy three months for Sprint after it reported a $629 million operating loss in the second quarter of the year. Since then, it's been bought out by Japanese carrier Softbank for $20.1 billion and has used some of the cash to regain a controlling stake in Clearwire.

Developing...

Filed under: Cellphones, Mobile

Sprint sells 1.5 million iPhones, 1 million other smartphones, but makes a net loss of $767 million originally appeared on Engadget on Thu, 25 Oct 2012 07:05:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/10/25/sprint-2012-q3/

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How Sugar Calories Affect Your Weight | Food Trients

Your body will never waste a calorie. Each calorie is either burned for energy or stored for later use. Calories come in three forms, which are the macromolecules of human nutrition: fat, protein and carbohydrates.

Carbohydrates?are interesting. The basic building block of all carbohydrates, whether simple or complex, is a single sugar molecule called glucose.

This means that all carbohydrates, from whole grains to table sugar, will eventually break down into a single glucose molecule.

Glucose?is the main energy source for all cells, including your heart, brain and muscles. But here?s where it gets interesting: Sugar, if it?s not burned immediately, can actually be stored in?two?forms.

Glucose Stores as Glycogen or Fat

Glycogen is one form in which the body stores excess glucose. Glycogen is a long chain of glucose molecules stored in mostly muscle tissue. But there?s a problem with storing sugar as glycogen. It requires water and the muscles have limited storage capacity.

To get around this, the human body developed a pathway to convert glucose into fat. That?s right ? sugar can become body fat. And eventually the increase in body fat will increase the number on your bathroom scale.

Burning sugar calories through exercise will make your body less likely to create body fat from excess sugar. But if we are honest, many of us don?t follow the recommendations of fitness experts to exercise 30?45 minutes, 3?4 times per week.

This means that leftover glucose will be converted into fat and an increase in weight is likely to follow.

Sugar is an Issue for All of Us

In case you?re thinking that excess sugar isn?t an issue for you, keep in mind that simple sugars can be found in?many?everyday products.

Anything in a box or a can is definitely going to contain an ample amount of simple sugars. Energy drinks, smoothies, low-fat foods, cereals, breads, teas and sodas are literally loaded with corn syrup and table sugar.

Again, all of this breaks down into the single sugar molecule called glucose. And if it?s not burned immediately, the body will eventually store it as glycogen or body fat.

So unless you?re carefully watching your diet, you?ll need to prevent sugar from reaching your bloodstream. The good news is that some specific foods and nutrients can accomplish just that.

Soluble Fiber Inhibits Sugar Absorption

To inhibit sugar absorption, first eat more?soluble fiber, which can be found in beans, legumes and sprouted grains. It?s a complex carbohydrate that has a unique property unlike other types of carbs.

Soluble fiber can swell in your gut and trap excess sugar calories. This not only prevents sugar from absorbing into your bloodstream, but also has the added benefit of making you feel full.

A very effective soluble fiber is called?propolmannan. It does a great job of trapping sugar calories and slowing the rapid emptying of ingested food into the small intestine, reducing the surge of glucose entering the bloodstream.

How does this translate into weight loss? In placebo-controlled human studies, those taking propolmannan before meals lost 5.5 to 7.92 pounds after eight weeks without changing their diets.

The placebo groups in these studies showed no significant weight loss. The propolmannan groups also showed reductions in blood lipid/glucose levels.^1,2

We suggest taking 2-4 grams of propolmannan right before your biggest meal of the day. This way you?ll inhibit sugar absorption and feel full faster.

What Other Nutrients Can Help with Sugar?

White kidney bean extract is another nutrient geared toward inhibiting sugar absorption.

In a study published in the?International Journal of Medical Science, white kidney bean extract was shown to inhibit sugar absorption and result in 6.5 pounds of weight loss and a loss of 2.1 inches in just 30 days.³

Green coffee extract?is another natural compound that holds a lot of promise. In fact, a 400 mg dose was shown to induce a remarkable 24% drop in after-meal blood sugar after 30 minutes while 200 mg generated a 14% drop.⁴

The reason is chlorogenic acid, a polyphenol found inside the green coffee bean.

Lastly, there?s African mango extract. It?s been shown to decrease appetite plus inhibit sugar and fat absorption. A study published in?Lipids in Health and Disease?showed that it can also inhibit fat cell creation.⁵

What You Need to Know

Even modestly elevated glucose has been shown to not only increase body fat composition, but to also be an independent predictor of cardiac death.

This underscores the need for?all?of us to pursue safe, effective,?natural?strategies to help bring blood sugar under control.

Fortunately, recent research has uncovered new interventions that help inhibit sugar absorption and decrease after-meal sugar spikes.

These may be worth looking into if countering the negative effects of sugar is something you?re interested in.

Life Extensionists are people who believe in taking advantage of documented scientific therapies to help maintain optimal health and slow aging. The medical literature contains thousands of references on the use of antioxidant vitamins, weight loss supplements, and hormones that have been shown to improve the quality and quantity of life. Life Extensionists attempt to take advantage of this scientific information to enhance their chances of living longer in good health.

Source: http://www.foodtrients.com/inside/how-sugar-calories-affect-your-weight/

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DNA's double stranded stretch: Models simulate what happens to DNA strands when stretched to the breaking point

ScienceDaily (Oct. 25, 2012) ? Theoretical physicists like to play with very unconventional toys. Manoel Manghi from Toulouse University in France and his colleagues have adopted a seemingly playful approach to examining what happens to a double stranded molecule of DNA when it is stretched to the breaking point, in a study about to be published in EPJ E.

Instead of using optical tweezers to stretch DNA as previously done in experimental settings, the authors focused on using a theoretical model to account for the structural deformations of DNA and determine how its mechanical characteristics could explain certain biological processes.

Over fifteen years ago, scientists discovered that DNA undergoes two structural transitions when pulled from both ends. The problem is that in experimental conditions these two transitions can overlap and can therefore be difficult to observe. Instead, Manghi and colleagues relied on a standard mathematical tool referred to as a 'coupled discrete wormlike chain-Ising model' to simulate DNA stretching and match experimental observations.

Thanks to their theoretical approach, the authors confirmed that after overcoming initial resistance to stretching, at a force of around 65 piconewtons (pN) in strength, the DNA stretches to almost twice its original length while also becoming less rigid. They also confirmed the other known structural transition occurring at around 135 pN. Although the critical forces of both transitions depend on the DNA sequence, they found it is the second one that most depends on it.

Beyond 135pN, DNA strands start peeling apart into single stranded DNAs that are similar to those obtained when DNA is heated up and undergoes thermal denaturation. This model thus bridges the gap between force-induced mechanical stretching and thermal denaturation and could potentially help understand how DNA performs its biological functions such as interaction with proteins and how it is packaged, say, in viruses.

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Story Source:

The above story is reprinted from materials provided by Springer.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Manoel Manghi, Nicolas Destainville, John Palmeri. Mesoscopic models for DNA stretching under force: New results and comparison with experiments. The European Physical Journal E, 2012; 35 (10) DOI: 10.1140/epje/i2012-12110-2

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/xNcXysgTxis/121025110156.htm

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Ole Miss facing possible self-imposed, NCAA penalties for women?s basketball

OXFORD ? As part of its ongoing investigation into recruiting and academic misconduct within the women?s basketball program, Ole Miss will look at possibly self-imposing violations.

That could be in addition to a process with the NCAA, which is also investigating the acts that led Ole Miss to firing head coach Adrian Wiggins and two staff members, as well as declaring two athletes ineligible for competition.

?There?ll be a process that we go through with the NCAA that will identify potential violations,? athletics director Ross Bjork said. ?We?ll look at self-imposing some violations as we go through the process here and learn more.

?There?ll be a formal notice of allegations from the NCAA that will come to us when the investigation is completed and then there?ll be a process through the committee on infractions or there could be another process that we could go through. And those things are yet to be determined.?

Wiggins was essentially fired Saturday, though he remains on administrative leave as the investigation continues. He will not return as the school?s head coach, and his termination is for-cause.

That leaves Ole Miss with no responsibility in terms of a buyout, though Bjork said it?ll pay Wiggins a monthly sum through March 31, 2013 that is based on his $250,000 annual salary from university coffers. Wiggins was also supposed to receiver $150,000 from the UMAA Foundation, but that is off the table.

There has also been no decision made yet on who will be the interim head coach for the 2012-13 season. Assistant coaches Brett Frank, Rebecca Kates-Taylor and Taja Edwards are currently leading the team.

?We?re looking at everything right now in terms of our options,? Bjork said. ?The great thing with our program is that we have great history. We can rely on great hall-of-famers, so we?re talking to as many people as we can including our current staff.?

Bjork also said the investigation began after the university received notice from the Southeastern Conference that there were allegations of violations. Asked if that meant a member institution first reported those allegations, Bjork said ?that?s part of the investigation and some of the things that we have to keep confidential.?

Assistant coach Kenya Landers and director of basketball operations Michael Landers were also fired Saturday for their role in the misconduct. Bjork maintained that Wiggins did not have complicit knowledge of what occurred, but pays the price for not knowing.

Source: http://blogs.clarionledger.com/um/2012/10/22/ole-miss-facing-possible-self-imposed-ncaa-penalties-for-womens-basketball/

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Medway community ed now enrolling for fall ? E-Flyer Site

For more than two decades, Medway Community Education has enriched the lives of local residents through creative and educational programs for all ages.

Its mission continues this fall with more than 75 classes and trips, ranging from preschool t-ball and chess for kids, to aqua zumba, basketball and bread baking.

Weve been very successful and we continue to grow. Its great, said Karen Niemczyk, assistant director of Medway Community Education. We try to keep the prices as low as possible, but always bring in the best instructors and best locations with clean facilities.

The programs, which are open to non-Medway residents at no additional fee, start at $25 and vary from one-day classes, to ongoing weekly sessions. Categories include preschool programs, youth general programs and fitness, teen programs, adult fitness, wellness, home and leisure, computers and technology, business and finance and trips.

The creative classes spark interest in newcomers, like beginner guitar and ukulele, and wreath 101. Other programs, such as intermediate sewing and photography, encourage people to further pursue their hobbies.

We love to work with the Medway Community Farm for farming classes, and we offer cooking classes, music classes. We try to cover every single thing, and weve been doing very well, Niemczyk said. Were consistently adjusting what we offer and adding new things, and if something has run its course, we find something else.

In addition to the leisurely programs, Medway Community Education provides educational resources, such as courses on college search strategies and financial aid, SAT preparation, first aid and CPR for teens and adults, drivers education, personal finance, and tutorials for new technology, like the iPad and iPhone.

Fitness programs, like co-ed volleyball and pilates, are always popular with all age groups, Niemczyk said.

There are also trips available, such as day excursions to New York City and Foxwoods Casino.

Different programs are offered each season, Niemczyk said, with many fall courses beginning in October. There is rolling registration for programs that have not yet started.

Visit Medway Community Education online and browse the fall brochure for detailed information on the many fall programs. Go to medwayschools.org , click on Community Education, and click on Fall Brochure.

Register online, by mail, or hand deliver registration and payment to the Burke-Memorial Schools main office between 7:30 am and 3:30 pm, at 16 Cassidy Lane, Medway.

Senior citizens get a 15 percent discount on courses only. Contact the office at 508-533-3222 option 4 with any questions about the programs.

Jessica Trufant can be reached at 508-634-7556 or JTrufant@wickedlocal.com.

Source: http://www.e-flyersite.com/?p=2846

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How To Raise Your Good Cholesterol | Psychology Today

Most people know it's important to get their bad cholesterol (LDL) down to reduce their risk of heart attacks and strokes. Fewer people know that it's also important to raise their good cholesterol (HDL) for the same reasons. Almost no one knows, however,? that a low HDL likely puts them at a higher risk for heart attacks and strokes than does a high LDL. In other words, it's more important to get your good cholesterol up than to get your bad cholesterol down.

In fact, though I can't find the reference from which it was taken, I remember when I was a resident seeing a graph put up at a talk that showed the greatest risk for having a heart attack comes not from a high LDL, not from hypertension, diabetes, or even smoking, but rather from a low HDL. A recent study supports the notion that a low HDL contributes more to atherosclerosis (hardening of the arteries) than does a high LDL.

Why, then, do physicians focus most of their discussion and interventions on lowering their patients' LDL and not raising their patients' HDL? The reason is simple: we don't have any drugs that have a significant effect on HDL. Exercise is known to raise HDL, but generally it must be of an intensity that in my own experience few patients are willing or able to maintain on a regular basis.

But recently, with the increasing popularity of low carbohydrate diets, a new, arguably less painful way to raise HDL?sometimes dramatically?has surfaced. It's long been known that another component of total cholesterol?triglycerides?have an inverse relationship to HDL. That is, as triglycerides go up, in general, HDL goes down, and vice versa. And while dietary interventions have little direct effect on HDL, they can have a large direct effect on triglycerides. And when triglycerides go down, HDL often goes up.

How do you reduce your triglycerides? There seem to be two main ways: 1) weight reduction and 2) a reduction in dietary intake of carbohydrates. Especially in people who are overweight or obese, reducing the amount of carbohydrate in the diet (especially sweets?sorry) reduces triglycerides?and in so doing often raises HDL.

Though I only have anecdotal evidence of this effect currently, I have a lot of it?including evidence in myself. After learning that my triglycerides were 165 and my HDL 37 (40 is considered the point below which a low HDL puts you at higher-than-average risk for a heart attack), I went on a low carbohydrate diet, lost twenty pounds, and lowered my triglycerides to 41 and raised my HDL to 71. Given that we consider an HDL over 60 to actually be protective against heart attacks, this is an astounding result. And one in medicine we've traditionally viewed as impossible. As weight loss has been shown to have more of an effect on LDL, I strongly suspect the rise in my HDL was due mostly to the reduction in my triglycerides, which in turn was due mostly to my reducing the amount of carbohydrate in my diet (I've held the frequency and intensity at which I exercise constant since the first measurement of my cholesterol was taken).

The good news in all of this is that we can exert far more influence over our cardiac destiny that we previously thought. The bad news, of course, is that altering our diets isn't easy. But for some, it's easier than regular exercise. And if my experience?as well as the experience of a number of my patients?is to be believed, the power of lowering triglycerides to raise HDL may equal, if not outstrip, the power of intense exercise to do the same.

?

Dr. Lickerman's new book The Undefeated Mind: On the Science of Constructing an Indestructible Self will be published on November 6. Please read the sample chapter and visit Amazon or Barnes & Noble to order your copy today!

Source: http://www.psychologytoday.com/blog/happiness-in-world/201210/how-raise-your-good-cholesterol

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Burglars hit Pa. house twice in 2 weeks, nab puppy

PHILADELPHIA (AP) ? Burglars have struck a Philadelphia house two weeks in a row, first stealing all the food in the family's refrigerator, then snatching their puppy.

Rachel Schortye tells WCAU-TV (http://bit.ly/TKmNcT ) that the latest theft happened late Saturday or early Sunday. She says the burglars took their 52-inch flat-screen TV, winter clothes and party favors for her 8-year-old son's upcoming birthday party.

Schortye says the thieves also took her 3-month-old puppy Miss Piggy from her cage. She says they entered the home through a screen on her porch.

The burglars first struck Oct. 15. Schortye says they entered through the unlocked front door and emptied the family's fridge.

Police say similar burglaries have been reported in the same neighborhood.

Schortye says she doesn't have the money to replace all that was stolen.

___

Information from: WCAU-TV, http://www.nbc10.com

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2012-10-21-Food-Puppy%20Snatchers/id-02e40787aa214bafa6c9d52e48dcca59

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Top security official among 8 dead in Beirut blast

A Lebanese rescue man, carries an injured boy at the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. A car bomb ripped through eastern Beirut on Friday, shearing the balconies off residential buildings and sending bloodied victims pouring out into the streets in the most serious blast this city has seen in years. (AP Photo/Hussein Malla)

A Lebanese rescue man, carries an injured boy at the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. A car bomb ripped through eastern Beirut on Friday, shearing the balconies off residential buildings and sending bloodied victims pouring out into the streets in the most serious blast this city has seen in years. (AP Photo/Hussein Malla)

Lebanese rescue workers and civilians carry an injured girl from the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. (AP Photo/Hussein Malla)

Injured Lebanese leave the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. Lebanese Red Cross and security officials say a car bomb in east Beirut has killed at least eight people and wounded dozens in the worst blast the city has seen in years, coming at a time when Lebanon has seen a rise in tension and eruptions of clashes stemming from the civil war in neighboring Syria. (AP Photo/Hussein Malla)

Lebanese soldiers inspect damaged buildings at the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. Lebanese Red Cross and security officials say a car bomb in east Beirut has killed at least eight people and wounded dozens in the worst blast the city has seen in years, coming at a time when Lebanon has seen a rise in tension and eruptions of clashes stemming from the civil war in neighboring Syria. (AP Photo/Bilal Hussein)

Lebanese firefighters extinguish burning cars at the scene of an explosion in the mostly Christian neighborhood of Achrafiyeh, Beirut, Lebanon, Friday Oct. 19, 2012. (AP Photo/Hussein Malla)

BEIRUT (AP) ? A powerful car bomb tore through the heart of Beirut's Christian sector Friday, killing a top security official and seven others in a devastating attack that threatened to bring the war in Syria directly to Lebanon's doorstep. The blast sheared the balconies off apartment buildings, upended cars and sent dazed rescue workers carrying bloodied children into the streets.

Dozens of people were wounded in the blast, the worst the Lebanese capital has seen in more than four years. The state-run news agency said the target was Brig. Gen. Wissam al-Hassan, head of the intelligence division of Lebanon's domestic security forces.

Al-Hassan, 47, headed an investigation over the summer that led to the arrest of former Information Minister Michel Samaha, one of Syria's most loyal allies in Lebanon.

"Whenever there is a problem in Syria, they want to bring it to us," said Karin Sabaha Gemayel, a secretary at a law firm a block from the bombing site, where the street was turned into a swath of rubble, twisted metal and charred vehicles.

"But you always hope it will not happen to us. Not again," she said.

Samaha is accused of plotting a campaign of bombings and assassinations in Lebanon at Syria's behest, to spread sectarian violence in Lebanon. Also indicted in the August sweep was one of the highest aides to Syrian President Bashar Assad.

A senior Lebanese police official, speaking anonymously because he was not authorized to talk to the media, said Samaha confessed to having personally transported explosives in his car from Syria to Lebanon with the purpose of killing Lebanese.

Analysts said al-Hassan's killing was a clear signal that Lebanon cannot insulate itself from the Syrian conflict, which has been the most sustained and powerful challenge to the 40-year Assad family dynasty.

"The regime in Damascus will look at his death with much comfort," said Ayham Kamel, a Middle East analyst at the Eurasia Group in London. "One figure, hostile to Syria's interests, is out of the picture."

In Washington, the Obama administration condemned "in the strongest terms" what it called a terrorist attack.

National Security Council spokesman Tommy Vietor said in a statement that there was "no justification for using assassination as a political tool," adding that the U.S. would stand with the Lebanese government in bringing to justice those responsible "for this barbaric attack."

Friday's blast also was a reminder of Lebanon's grim history, when the 1975-1990 civil war made the country notorious for kidnappings, car bombs and political assassinations. Since the war's end, Lebanon has been a proxy battleground for regional conflict, and the Mediterranean seaside capital has been prey to devastating violence shattering periods of calm.

Friday's explosion ripped through a narrow street at midafternoon in Beirut's mainly Christian Achrafieh neighborhood, an area packed with cafes and shops. Doors and windows were shattered for blocks, and several blackened cars appeared to have been catapulted through the air.

Bloodied residents fled their homes while others tried to help the seriously wounded. One little girl, apparently unconscious and bleeding from her head, was carried to an ambulance in the arms of a rescue worker, her white sneakers stained with blood.

Al-Hassan's body was so disfigured in the blast that his bodyguards only recognized him from his sneakers, said a paramedic at the scene.

A Lebanese security official said al-Hassan, who was married with two children, had just returned from visiting family in Paris. He was either on his way to or from work in a non-armored car with his driver, who also was among the dead, said the official, who spoke on condition of anonymity because he was not authorized to give information to the media.

At a nearby hospital, George Hadar was waiting for his 27-year-old daughter to get out of surgery for her wounds ? including facial injuries from flying glass and the loss of her eye. His granddaughter, 5-year-old Christa, sat in his lap, her yellow Mickey Mouse shirt covered with blood.

"I hear journalists on the radio talking about body parts and corpses all over the place where my daughter lives," Hadar said. "I drove down here in a daze."

There were immediate fears that Friday's violence could lay bare seething sectarian tensions in Lebanon. The countries share a complex web of political and sectarian ties and rivalries, often causing events on one side of the border to echo on the other.

Many of Lebanon's Sunnis have backed Syria's mainly Sunni rebels, while Shiites have tended to back Assad. Al-Hassan was a Sunni whose stances were widely seen to oppose Syria and the country's most powerful ally in Lebanon, the Shiite militant group Hezbollah.

Soon after the blast erupted, crowds began blocking roads, burning tires and shooting in the air in Sunni areas of Beirut and northern Lebanon. In the eastern Bekaa Valley, angry protesters closed the border crossing that links Lebanon with Syria.

In the northern Lebanese city of Tripoli, pro- and anti-Syrian groups fought with rocket-propelled grenades and automatic rifles. One person was killed, according to security officials. Elsewhere, clashes pitted gunmen in a Sunni neighborhood against those in an Alawite neighborhood of the city. Assad belongs to the tiny Alawite sect, an offshoot of Shiite Islam.

Even as the rubble smoldered in Beirut, Lebanon's fractious political leaders began taking sides. Syria ally Hezbollah condemned the attack and expressed a "state of great shock over this terrible terrorist crime."

But the anti-Syrian blocs placed the blame squarely on Assad.

Former Prime Minister Saad Hariri, a Sunni politician whose powerful father was assassinated in 2005 in a massive truck bombing along the Beirut waterfront, said the Lebanese people must not remain silent about this "heinous crime."

Asked who he blamed, Hariri said: "Bashar Hafez Assad."

Speaking to the Al Arabiya TV station, Walid Jumblatt, leader of the Druse sect, also accused Assad of being behind the killing.

"He is telling us that even though he turned Syria into rubble, 'I am ready to kill in any place'" Jumblatt said.

For much of the past 30 years Lebanese have lived under Syrian military and political domination.

That grip began to slip in 2005, when former Prime Minister Rafik Hariri was assassinated. Syria was widely accused of involvement ? something it has always denied ? and Damascus was forced to withdraw its troops.

But the killings of anti-Syrian figures continued for several years, and opponents of Assad say he has maintained his influence through proxies in the government.

"The fate of Syria and Lebanon were, are and will always be inextricably linked, for better or worse," said Bilal Saab, a Syria expert at the Monterey Institute of International Studies.

The last major bombing was in 2008, when a car bomb killed a senior Lebanese anti-terror police official who was investigating dozens of other bombings. Four others were killed and 38 wounded in the blast in the Christian Hazmieh neighborhood.

After that, there was relative calm until the uprising against Assad began in March 2011. Since then, there have been sporadic gun battles between pro- and anti-Assad factions, particularly in northern Lebanon.

The explosion shocked a city known for its rollicking nightlife into silence Friday night, as streets that normally would have been packed with cars and partygoers were largely deserted.

"I'm very worried about the country after this explosion," Beirut resident Charbel Khadra said. "I'm worried the explosions will return ? and this is just the first one."

"It is a message," said Marwan Rifa, who was working as a legal assistant near the explosion site. "And the message is, you will never live in peace."

___

AP writers Ben Hubbard and Barbara Surk contributed to this report from Beirut.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-10-19-Lebanon/id-adb24dabf1804f2db4d12bc471ffc32d

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Advanced age doesn't have to hold you back from new employment

For the first time in our nation?s history, older adults are now the fastest-growing segment of our population. Every day, 10,000 Baby Boomers turn 65.

Unfortunately, one in every five people 65 and older lives on an average of $7,500 a year. Social Security recipients will only see a very slight cost-of-living adjustment in those benefits in 2013.

The Government Accountability Office reports that the number of unemployed adults 55 and older has doubled in the past five years.

All this adds up to the need for older adults, many of them 65 and older, to find work.

If you are an older adult, here are seven things you can do to improve your chances of finding work:

• Creatively expand the list of skills you possess based on your background and your years of experience. Fully taking into consideration your skills that are transferable to other jobs is critical in today?s job market.
• List the companies that typically hire those jobs skills.
• At a minimum, use traditional networking to determine who does the hiring for the companies you are interested in.
• If you are computer savvy, use Facebook, LinkedIn and other social network sites as part of your networking effort.
• Contact those companies. Do not ask if they have job openings. Ask to meet with them to discuss their business, their industry or to get career advice. Ask for 10 minutes of their time and only take 10 minutes of their time.
• If your contacts and meetings lead to a job interview, focus on your dependability and your desire to work hard. Let the interviewer know how many more years you plan to work. Most employers do not expect more than six or seven years for any new employee for any given job.
• Contact a One-Stop Career Center for help in your job preparation and search.

The Labor Department provides One-Stop Career Centers in all 50 states. These centers provide free computer training and other services for older adults. The computer courses alone can make older adults more confident about their skills while giving them credentials to show prospective employers.

The Department of Workforce Services provides One-Stop Career Centers in Clearfield, Ogden, Roy, Brigham City and Logan. These centers offer a full range of employment services for both those seeking jobs and for employers seeking to hire.

As the fastest-growing segment of our population, older adults are facing more challenges than at any time since the Great Depression, but thankfully, services are available to help.

Ron Campbell has worked extensively in the job preparation and job search industry. He can be reached at 801-386-1111 or campbellrv@gmail.com.

Source: http://www.standard.net/stories/2012/10/19/advanced-age-doesnt-have-hold-you-back-new-employment

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Business networking

I know there are people from all walks of life on this forum. I want to be able to have people work with one another to help build our business. If you know anyone looking for some help or you know of a good deal please post it on here. If you have any question or need advice on something post it and see if there are ay professionals in the industry that can help.

I will start.

My name is Josh Preston and I am in the insurance industry. I do personal lines, commercial, small business and non-profit insurance. If you have any questions about insurance please let me know and I will answer them the best that I can. If I do not know the answer I will find out the answer for you and let you know.

My email is josh(at)properlyinsured.com feel free to email me any questions.

Source: http://www.southbayriders.com/forums/showthread.php?t=126316

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Dr. Don Cleveland of Ludwig Institute for Cancer Research elected to Institute of Medicine

Public release date: 15-Oct-2012
[ | E-mail | Share ]

Contact: Rachel Steinhardt
rsteinhardt@licr.org
646-371-7394
Ludwig Institute for Cancer Research

New York, NY, October 15, 2012Don W. Cleveland, PhD, Member of the Ludwig Institute for Cancer Research and chair of the UC San Diego Department of Cellular and Molecular Medicine has been elected to the Institute of Medicine (IOM). Election to the IOM is one of the highest honors in the fields of health and medicine.

Established in 1970 by the National Academy of Sciences, the IOM serves as an advisory organization to Congress and policy makers on important health questions. During the past year projects included health IT and patient safety, treatment of post-traumatic stress disorder, nutrition rating systems and graphics on food packaging, and studies of environmental factors in breast cancer.

Cleveland's pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease, led to his being named to the American Academy of Arts & Sciences and the National Academy of Sciences in 2006.

Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment known as ASO (short for antisense oligonucleotide) blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

Cleveland received his Ph.D. in biochemistry from Princeton University. Following his post-doctoral work at UC San Francisco, he was a professor at Johns Hopkins University School of Medicine until joining the Ludwig Institute for Cancer Research at UC San Diego in 1995.

###

About the Ludwig Institute for Cancer Research

The Ludwig Institute is an international non-profit organization committed to improving the understanding and control of cancer through integrated laboratory and clinical discovery. Leveraging its worldwide network of investigators and the ability to sponsor and conduct its own clinical trials, the Institute is actively engaged in translating its discoveries into applications for patient benefit. Since its establishment in 1971, the Institute has expended more than $1.5 billion on cancer research. http://www.licr.org

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 15-Oct-2012
[ | E-mail | Share ]

Contact: Rachel Steinhardt
rsteinhardt@licr.org
646-371-7394
Ludwig Institute for Cancer Research

New York, NY, October 15, 2012Don W. Cleveland, PhD, Member of the Ludwig Institute for Cancer Research and chair of the UC San Diego Department of Cellular and Molecular Medicine has been elected to the Institute of Medicine (IOM). Election to the IOM is one of the highest honors in the fields of health and medicine.

Established in 1970 by the National Academy of Sciences, the IOM serves as an advisory organization to Congress and policy makers on important health questions. During the past year projects included health IT and patient safety, treatment of post-traumatic stress disorder, nutrition rating systems and graphics on food packaging, and studies of environmental factors in breast cancer.

Cleveland's pioneering discoveries of the mechanisms of chromosome movement and cell-cycle control during normal cellular division, as well as of the principles of neuronal cell development and their relationship to the defects that contribute to inherited neurodegenerative disease, led to his being named to the American Academy of Arts & Sciences and the National Academy of Sciences in 2006.

Most recently, his research has achieved a significant breakthrough in treating Huntington's disease, an inherited and degenerative brain disorder for which there is no cure. A one-time injection of a new DNA-based drug treatment known as ASO (short for antisense oligonucleotide) blocked the activity of the gene whose mutation causes the disease. A single treatment silenced the mutated gene responsible for the disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

Cleveland received his Ph.D. in biochemistry from Princeton University. Following his post-doctoral work at UC San Francisco, he was a professor at Johns Hopkins University School of Medicine until joining the Ludwig Institute for Cancer Research at UC San Diego in 1995.

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About the Ludwig Institute for Cancer Research

The Ludwig Institute is an international non-profit organization committed to improving the understanding and control of cancer through integrated laboratory and clinical discovery. Leveraging its worldwide network of investigators and the ability to sponsor and conduct its own clinical trials, the Institute is actively engaged in translating its discoveries into applications for patient benefit. Since its establishment in 1971, the Institute has expended more than $1.5 billion on cancer research. http://www.licr.org

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Source: http://www.eurekalert.org/pub_releases/2012-10/lifc-ddc101212.php

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